Novel fabricated potentiometric sensors for selective determination of carbinoxamine with different greenness evaluation perspectives

• Published in: Microchemical journal 2023-04, Vol.187, p.108381, Article 108381
• Main Authors: Soliman, Rabab M., Rostom, Yasmin, Mahmoud, Amr M., Fayez, Yasmin M., Mostafa, Nadia M., Monir, Hany H.
• Format: Article
• Language: English
• Subjects: Carbinoxamine maleate; Greenness assessment; Ion selective membranes; Microfabrication; Multiwall carbon nanotubes; Solid contact electrode
• ISSN: 0026-265X; 1095-9149
• DOI: 10.1016/j.microc.2022.108381

[Display omitted] •First potentiometric sensing platform for in situ monitoring of CRX.•Full investigation of the opportunities and challenges offered by the dual designs, liquid inner contact and solid state sensors.•MWCNTs is a promising candidate as a transducer material for an innovative disposal microfabricated electrode.•The proposed sensors have been successfully employed in the selective determination of CRX in pure powder form and combined formulation.•Declaration of method sustainability via using GAM, Eco-Scale, GAPI, AGREE, and RGB12 model. Electrochemical sensors, such as ion-selective electrodes (ISEs) is one of the promising green analytical techniques with significant advances that opens up new frontiers of its application. In this contribution, we developed and validated novel potentiometric sensing method for selective monitoring of carbinoxamine maleate (CRX) in presence of the co-formulated drugs. A comparative potentiometric study was employed using a dual design of ISEs; a classical liquid inner-contact and solid-contact sensors. Herein, a full investigation of the opportunities and challenges offered by the two ISEs assemblies and configurations were discussed. Taking into consideration the impressive added values of solid-contact ISEsover the conventional ones, including: being eco-friendly, real-time analyzers, portable, disposal, maintenance-free, easily miniaturized, and compatible with microfabrication technologies. The backbone of the solid contact electrode is the incorporation of ionophore (2-hydroxypropyl-β-cyclodextrin) as supramolecular element and a network of multi-walled carbon nanotubes as ion-to-electron transducer in a single-piece nanocomposite membrane. Besides, the fabrication of solid-state ISEs was performed via simple one-step drop casting of the ion sensing mixture on surface of microfabricated electrode.Furthermore, the morphological and structural features of the obtained membrane were characterized using Raman spectroscopy and scanning electron microscopy (SEM) techniques. The suggested sensors were successfully applied for quantitation of CRX in its pure and dosage form. Performances of fabricated sensors were assessed as per IUPAC recommendations. The outcomes of the proposed method were statistically benchmarked to the official approach, where no significant difference was found. Moreover, a comprehensive greenness evaluation of the investigated method was performed via various green-metrics, namely, GAM