A green microfluidic method for the simultaneous extraction of polar and non-polar basic compounds in biological samples

[Display omitted] •A novel green microfluidic method for simultaneous extraction of non-polar and polar basic pharmaceuticals is presented.•A new SLM based on camphor and menthol-based SLMs was efficient for the extraction of all compounds.•The microfluidic extraction system showed good long-term st...

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Bibliographic Details
Published in:Microchemical journal 2023-06, Vol.189, p.108553, Article 108553
Main Authors: Martín, Alejandro, Santigosa, Elia, Ramos-Payán, María
Format: Article
Language:English
Subjects:
Eutectic solvent
Liquid phase microextraction
Microfluidic
Pharmaceuticals
Supported liquid membrane
Urine samples
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Summary:[Display omitted] •A novel green microfluidic method for simultaneous extraction of non-polar and polar basic pharmaceuticals is presented.•A new SLM based on camphor and menthol-based SLMs was efficient for the extraction of all compounds.•The microfluidic extraction system showed good long-term stability and allowed consecutive extractions.•High recoveries and good clean-up were obtained from human urine samples. Microfluidic devices as sample treatment have showed significant advancements in recent years, becoming an important tool in pharmaceutical analysis. In this work, a green microfluidic method for the simultaneous extraction of basic polar and non-polar compounds is proposed for the first time, offering a new and more sustainable and environmentally friendly alternative. A mixture of camphor:menthol 1:1 is presented as a new green supported liquid membrane (SLM) for the simultaneous extraction of a wide log P range for basic compounds (0.4 
ISSN:0026-265X
1095-9149
DOI:10.1016/j.microc.2023.108553