Facile synthesis of magnetic layered double hydroxide/metal–organic framework MIL-100(Fe) for simultaneous extraction and enantiomeric determination of three chiral triazole fungicides in water and juice samples

• Published in: Microchemical journal 2024-06, Vol.201, p.110599, Article 110599
• Main Authors: Zhou, Li, Tang, Jing, Chen, Tong, Peng, Jiahui, Guo, Hainan, Zhang, Ronghui, Lv, Xinyu, Fan, Ronghua
• Format: Article
• Language: English
• Subjects: Enantioselective analysis; Layered double hydroxides; Magnetic solid-phase extraction; Metal-organic framework MIL-100(Fe); Triazole fungicides
• ISSN: 0026-265X
• DOI: 10.1016/j.microc.2024.110599

[Display omitted] •Magnetic layered double hydroxide/metal–organic framework was prepared for simultaneous enrichment of triazole fungicides.•This is the first method for enantiomeric analysis of paclobutrazol, uniconazole and bromuconazole.•The molecular docking technology was used to interpret the adsorption mechanism between MIL-100(Fe) and triazole fungicides.•The developed enantioselective method was suitable for water and juice monitoring. For the first time, magnetic layered double hydroxide/metal–organic framework (Fe3O4@CuZnAl-LDH@MIL-100(Fe)) was successfully fabricated and applied for enrichment of triazole fungicides from water and juice samples prior to chiral HPLC-UV analysis. Several key parameters influencing the extraction efficiency including extraction time, desorption time, sample solution pH, the ionic strength of sample solution, adsorbent amount, desorption volume, desorption solvent and sample volume were investigated by Plackett-Burman design and Box-Behnken design. Under the optimum conditions, the limit of detections (LODs) and limit of quantifications (LOQs) were in the ranges of 0.35 to 1.20 μg L−1 and from 1.00 to 3.80 μg L−1, respectively. The average spiked recoveries and enrichment factors ranged from 86.28-98.22 % and 21.6–23.8, respectively. The linearity was in the range of (5–1000 μg L−1) with satisfactory correlation coefficients (R2) values (0.9987–0.9999) and a good precision (RSDs ≤ 5.74 %). Moreover, the computational simulation was first employed to analyze adsorption properties of MIL-100(Fe) against triazole fungicides. This work provides a promising method for trace chiral pesticide analysis in aqueous samples.