Multichannel sensor array based on carbon dots and metal ions system for physiological phosphates sensing

• Published in: Microchemical journal 2024-12, Vol.207, p.111992, Article 111992
• Main Authors: Huang, Li, Huang, Ting, Liao, Junyu, Liu, Meiling, Zhang, Youyu, Zhu, Xiaohua, Yao, Shouzhuo
• Format: Article
• Language: English
• Subjects: Carbon dots; Metal ions; Physiological phosphates; Sensor array
• ISSN: 0026-265X
• DOI: 10.1016/j.microc.2024.111992

[Display omitted] •Three-color emitting carbon dots (CDs)-metal ion pairs were prepared as a fluorescent sensor array.•Effective discrimination of five physiological phosphates can be realized in a single “well”.•The multichannel sensor array can be used to identify physiological phosphates in serum media. The detection of physiological phosphates is crucial for elucidating metabolic processes and related diagnoses of diseases. Herein, a carbon dots (CDs) modulated multichannel fluorescent sensor array was proposed for detecting and distinguishing physiological phosphates. In this sensor, three metal ions (Nd3+, Ag+, and Fe3+) with significantly different binding forces with phosphate ions were selected to trigger fluorescence quenching of three CDs (BCDs, GCDs, and RCDs). Upon adding physiological phosphates, the fluorescence intensity of CDs changed. Depending on the discrepancy in the content of phosphate units in different physiological phosphates, the sensor array realized the detection and differentiation of five physiological phosphates related to adenosine triphosphate (ATP) hydrolysis, and has good anti-interference ability, which can realize the differentiation of physiological phosphates in complex serum samples.