Electrochemical sensor based on Ni3S2-MoS2 hollow nanospheres for sensitive detection of acetaminophen

• Published in: Microchemical journal 2025-01, Vol.208, p.112487, Article 112487
• Main Authors: Chen, Yifan, Liu, Li, Yan, Xiaoxia, Li, Kexin, Deng, Dongmei, He, Haibo, Lei, Yunyi, Luo, Liqiang
• Format: Article
• Language: English
• Subjects: Acetaminophen analysis; Electrochemical sensor; Electrooxidation; Hollow structure; Ni3S2-MoS2 composites
• ISSN: 0026-265X
• DOI: 10.1016/j.microc.2024.112487

[Display omitted] •Ni3S2-MoS2 hollow nanospheres were synthesized by sacrificial template method.•Ni3S2-MoS2 displayed excellent electrocatalytic performance towards the oxidation of acetaminophen.•Acetaminophen can be measured in the range from 0.8 to 1750 μM with detection limit of 0.093 μM.•The as-proposed sensor suggests a favorable practical application prospect. This work presents the synthesis and characterization of Ni3S2-MoS2 composite hollow nanospheres by sacrificial template method for sensitive electrochemical detection of acetaminophen. The Ni3S2-MoS2 hollow nanospheres were synthesized using SiO2 template, providing a high specific surface area and facilitating electrochemical sensing due to increased electrochemically active area and higher conductivity. The constructed electrochemical sensor based on synthesized Ni3S2-MoS2 composite hollow nanospheres exhibited excellent electrochemical oxidation ability for acetaminophenol, and the linear ranges were 0.8 − 70 μM and 70 − 1750 μM, respectively. The sensitivities were 977.98 μA mM−1 cm−2 and 441.67 μA mM−1 cm−2, respectively. In addition, the sensor possessed low detection limit (0.093 μM) with superior selectivity, along with reproducibility and stable endurance over time. Meanwhile, the constructed sensor has been applied for the detection of acetaminophen in real samples, implying practical prospects.