Novel application of HKUST-1 metal–organic framework as antifungal: Biological tests and physicochemical characterizations

[Display omitted] ► Metal–organic framework with antifungal activity. ► Growth inhibition of yeast and mold. ► Slow MOF degradation producing extra-framework Cu(I). ► Controlled release of Cu ions. The HKUST-1 metal–organic framework (MOF) was successfully applied as a biocidal material against repr...

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Bibliographic Details
Published in:Microporous and mesoporous materials 2012-11, Vol.162, p.60-63
Main Authors: Chiericatti, Carolina, Basilico, Juan Carlos, Zapata Basilico, María L., Zamaro, Juan Manuel
Format: Article
Language:English
Subjects:
Antifungal activity
Chemistry
Colloidal state and disperse state
Copper release
Exact sciences and technology
General and physical chemistry
HKUST-1
Metal–organic framework
Porous materials
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Summary:[Display omitted] ► Metal–organic framework with antifungal activity. ► Growth inhibition of yeast and mold. ► Slow MOF degradation producing extra-framework Cu(I). ► Controlled release of Cu ions. The HKUST-1 metal–organic framework (MOF) was successfully applied as a biocidal material against representative yeast and mold. The synthesized MOF showed a strong antifungal effect against Saccharomyces cerevisiae for which the growth was completely inhibited, whereas the growth of Geotrichum candidum was reduced from 6.16 to 1.29CFUmL−1. The antifungal action was related to copper ions released into the culture medium due to a progressive degradation of the crystalline structure of the material that involved the formation of surface extra-framework Cu(I). This study shows the potential of using copper-based metal–organic frameworks for a controlled release of biologically active copper ions.
ISSN:1387-1811
1873-3093
DOI:10.1016/j.micromeso.2012.06.012