Controlled release of ferulic acid from a hybrid hydrotalcite and its application as an antioxidant for human fibroblasts

Released ferulic acid from a hybrid layered double hydroxide reduces significantly the reactive oxygen species in human fibroblasts. Inhibition of oxidation occurs for periods as long as 24h. •Ferulic acid was intercalated in a zinc–aluminium layered double hydroxide.•The ferulic acid is controlled...

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Bibliographic Details
Published in:Microporous and mesoporous materials 2013-11, Vol.181, p.1-7
Main Authors: Lima, Enrique, Flores, Jorge, Cruz, Alejandra Santana, Leyva-Gómez, Gerardo, Krötzsch, Edgar
Format: Article
Language:English
Subjects:
Antioxidants
Biological and medical sciences
Ferulic Acid
Fibroblasts
General pharmacology
Hydrotalcite
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
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Summary:Released ferulic acid from a hybrid layered double hydroxide reduces significantly the reactive oxygen species in human fibroblasts. Inhibition of oxidation occurs for periods as long as 24h. •Ferulic acid was intercalated in a zinc–aluminium layered double hydroxide.•The ferulic acid is controlled released from HDL under a biological media.•Released ferulic acid inhibits oxidation of human fibroblasts.•Oxidation of human fibroblasts is prevented for long time because of the controlled releasing. Ferulic acid anions were intercalated in a Zn–Al layered double hydroxide. The materials generated by this process were characterised structurally and tested in two important applications: as in vitro drug delivery agents in a system that mimics biological conditions, for which a mathematical model describing the drug delivery profile was created, and as antioxidants for human fibroblasts.
ISSN:1387-1811
1873-3093
DOI:10.1016/j.micromeso.2013.07.014