Hydrotalcite-gated hollow mesoporous silica delivery system for controlled drug release

• Published in: Microporous and mesoporous materials 2019-01, Vol.274, p.304-312
• Main Authors: Jin, Li, Huang, Qing-Jun, Zeng, Hong-Yan, Du, Jin-Ze, Xu, Sheng, Chen, Chao-Rong
• Format: Article
• Language: English
• Subjects: Hollow mesoporous silica; Hydrotalcite; Kinetics; pH-sensitivity drug release
• ISSN: 1387-1811; 1873-3093
• DOI: 10.1016/j.micromeso.2018.09.001

Hollow mesoporous silica (HMS) composed of a hollow cavity and mesoporous shell available for drug storage. The MgAl-LDH as a gatekeeper coated on the HMS outer surface by the layer-by-layer selfassembly method, encapsulated the anticancer drug 5-Fluorouracil (5-FU) within the HMS cavities and pores to get the pH-controlled drug release system (FU/HMS@LDH) for minimizing premature release of 5-FU. The structures, morphology, texture and 5-FU release behavior were characterized and investigated with various techniques. The kinetic data revealed that the targeted 5-FU release by the LDH-gated HMS release system (FU/HMS@LDH) stemmed from the dissolution of the LDH nanosheets upon decrease in pH and cleavage of the hydrogen bonds, indicating that the pH-responsive controlled release of 5-FU could be stimulated by acidic environments. These results suggested that the FU/HMS@LDH release system had the potential as an anticancer drug delivery system in targeted drug release for tumor chemotherapy. [Display omitted] •Hydrotalcite-gated hollow mesoporous silica delivery system (FU/HMS@LDH) with pH-sense was successfully prepared.•The drug-loading pore channels can be closed and opened at will due to the pH-sense of the FU/HMS@LDH.•The FU/HMS@LDH can release sustainedly at pH 4.6, basically completely release at pH 2.4, and had ‘‘almost zero release’’ property (pH 7.4).