Bioactive molecule encapsulation on metal-organic framework via simple mechanochemical method for controlled topical drug delivery systems

• Published in: Microporous and mesoporous materials 2020-08, Vol.302, p.110199, Article 110199
• Main Authors: Noorian, Seyyed Abbas, Hemmatinejad, Nahid, Navarro, Jorge A.R.
• Format: Article
• Language: English
• Subjects: Antibacterial; Anticancer; Drug delivery system; Mechanochemical process; Metal-organic frameworks
• ISSN: 1387-1811; 1873-3093
• DOI: 10.1016/j.micromeso.2020.110199

The robust [Zn4O(3,5-dimethyl-4-carboxypyrazolato)3] ([Zn4O(dmcapz)3]) 3D metal-organic framework (MOF) is studied as a suitable platform for the controlled release of bioactive molecules. With this aim, a simple ball milling technique is used to efficiently encapsulate the model drugs 5-fluorouracil, caffeine, para-aminobenzoic acid, and benzocaine. Both computational and experimental studies confirm the suitability of [Zn4O(dmcapz)3] to incorporate high loadings of the studied bioactive molecules. The results show that the physicochemical properties of bioactive molecule effects on the loading efficiency on the MOF structure. The controlled release of the bioactive molecules from drug@[Zn4O(dmcapz)3] is studied under simulated cutaneous conditions to prove its suitability as topical drug delivery systems. In this regard, 5-fluorouracil@[Zn4O(dmcapz)3] system is incorporated in the preoxidized cellulosic fabric to demonstrate their possible application for antibacterial treatment and skin cancer therapy. The results show that the 5-fluorouracil@[Zn4O(dmcapz)3] loaded cellulosic fabrics exhibit potentially significant anticancer and antibacterial activities. [Display omitted] •A mechanochemical technique efficiently encapsulates the model bioactive molecule.•Different uptake behavior highlights the importance of drug-framework interaction.•Controlling drug delivery is affected by the physicochemical properties of cargoes.•Cellulose substrate is preoxidized to attain the carboxyl functional group.•5-fluorouracil@MOF applied on cellulose for skin cancer and antibacterial treatment.