Facile synthesis of novel fluorescent organosilica-coated MOF nanoparticles for fast curcumin adsorption

Nano metal-organic framework materials are progressively being investigated and used as drug carriers in the biomedical field. Curcumin, an active component derived from turmeric, is commonly utilized in traditional medicine and can support cancer treatment. In this study, ZIF-8 nanomaterial was eff...

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Bibliographic Details
Published in:Microporous and mesoporous materials 2022-06, Vol.338, p.111944, Article 111944
Main Authors: Nguyen, Trang Thi Thu, Le, Bao Quang Gia, Dang, Minh-Huy Dinh, Phan, Bach Thang, Mai, Ngoc Xuan Dat, Doan, Tan Le Hoang
Format: Article
Language:English
Subjects:
Adsorption
Curcumin
Metal−organic frameworks
Periodic mesoporous organosilica
Surface functionalization
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Summary:Nano metal-organic framework materials are progressively being investigated and used as drug carriers in the biomedical field. Curcumin, an active component derived from turmeric, is commonly utilized in traditional medicine and can support cancer treatment. In this study, ZIF-8 nanomaterial was effectively modified with fluorescence organosilica coating, named ZIF-8@BPMO, to promote bio-interaction and prevent material flocculation. Powder X-ray diffraction (PXRD), infrared spectroscopy (FT-IR), differential gravimetric analysis (TGA), and isothermal nitrogen adsorption at 77 K were utilized to investigate the synthesized materials. Property analysis revealed that ZIF-8@BPMO nanomaterials had high crystallinity, a large surface area, and a high thermal stability with a particle size of 100 nm. According to the research, this material had high curcumin adsorption capacity of 666 mg g-1 for 15 min. Curcumin adsorption on the nanomaterial followed a pseudo-second-order kinetic model and the Freundlich model. Furthermore, thermodynamic investigations demonstrated an endothermic and spontaneous adsorption mechanism. These results indicate that the fluorescent ZIF-8@BPMO nanoparticle is a potential material for bio-applications. [Display omitted] •New fluorescent ZIF-8@BPMO nanomaterial was successfully synthesized and characterized.•Particle sizes of ZIF-8@BPMO could be less than 100 nm.•The nanomaterial showed high loading capacity of curcumin (666 mg g−1).•Kinetics, thermodynamics, and mechanism of curcumin adsorption on the nanomaterial were studied.
ISSN:1387-1811
DOI:10.1016/j.micromeso.2022.111944