Alkene- and alkyne-bridged mimics of nisin as potential peptide-based antibiotics

Here we highlight our recent results of the application of ring-closing metathesis and ring-closing alkyne metathesis in biologically relevant biomolecules in order to introduce alkene- and/or alkyne bridges as novel covalent constraints for stabilizing their bioactive conformation and increasing th...

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Bibliographic Details
Published in:Journal of molecular catalysis. A, Chemical Chemical, 2006-07, Vol.254 (1), p.68-77
Main Authors: Ghalit, Nourdin, Rijkers, Dirk T.S., Liskamp, Rob M.J.
Format: Article
Language:English
Subjects:
Chemistry
Exact sciences and technology
Organic chemistry
Peptide-based antibiotics
Peptides
Peptidomimetics
Preparations and properties
Ring-closing alkene metathesis
Ring-closing alkyne metathesis
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Summary:Here we highlight our recent results of the application of ring-closing metathesis and ring-closing alkyne metathesis in biologically relevant biomolecules in order to introduce alkene- and/or alkyne bridges as novel covalent constraints for stabilizing their bioactive conformation and increasing their metabolic stability. ▪ Here we highlight our recent results of the application of ring-closing metathesis and ring-closing alkyne metathesis (RCAM) in biologically relevant biomolecules in order to introduce alkene- and/or alkyne-bridges as novel covalent constraints for stabilizing their bioactive conformation and increasing their metabolic stability.
ISSN:1381-1169
1873-314X
DOI:10.1016/j.molcata.2006.03.029