An efficient one-pot synthesis of polyhydroquinoline derivatives through the Hantzsch four component condensation

A straightforward and general method has been developed for the synthesis of polyhydroquinolines derivatives by simply combining aldehyde, ethyl acetoacetate, dimedone, and ammonium acetate in the presence of a catalytic amount of scandium triflate. This method is very easy, rapid, and high yielding...

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Bibliographic Details
Published in:Journal of molecular catalysis. A, Chemical Chemical, 2006-08, Vol.256 (1), p.309-311
Main Authors: Donelson, James L., Gibbs, Richard A., De, Surya K.
Format: Article
Language:English
Subjects:
Catalysis
Chemistry
Exact sciences and technology
General and physical chemistry
Hantzsch reaction
Polyhydroquinoline
Scandium triflate
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Summary:A straightforward and general method has been developed for the synthesis of polyhydroquinolines derivatives by simply combining aldehyde, ethyl acetoacetate, dimedone, and ammonium acetate in the presence of a catalytic amount of scandium triflate. This method is very easy, rapid, and high yielding reaction for the synthesis of polyhydroquinolines.
ISSN:1381-1169
1873-314X
DOI:10.1016/j.molcata.2006.03.079