Biocatalyzed irreversible esterification in the preparation of S-naproxen

Dimethyl carbonate was used as alcohol donor in the esterification of naproxen in the presence of immobilised lipase B from Candida antarctica (Novozym 435). The conjugation of hydrolysis of dimethyl carbonate and esterification of acid, created irreversible operative conditions so permitting the re...

Full description

Saved in:
Bibliographic Details
Published in:Journal of molecular catalysis. B, Enzymatic Enzymatic, 2010-08, Vol.65 (1), p.49-51
Main Authors: Morrone, R., D’Antona, N., Lambusta, D., Nicolosi, G.
Format: Article
Language:English
Subjects:
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Dimethyl carbonate
Fundamental and applied biological sciences. Psychology
Irreversible esterification
Lipase
Methods. Procedures. Technologies
Naproxen
NSAID
Profen
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dimethyl carbonate was used as alcohol donor in the esterification of naproxen in the presence of immobilised lipase B from Candida antarctica (Novozym 435). The conjugation of hydrolysis of dimethyl carbonate and esterification of acid, created irreversible operative conditions so permitting the recovery of S-naproxen in high ee (>98%). The adopted procedure has a general use.
ISSN:1381-1177
1873-3158
DOI:10.1016/j.molcatb.2010.01.014