An efficient practical chemo-enzymatic protocol for the synthesis of pyrazoles in aqueous medium at ambient temperature

•This is the first eco-efficient report for the synthesis of title compounds using biocatalysis.•Synthesis of pyrazole structural motifs expedited by fermenting baker's yeast.•The role of baker's yeast in the reaction mechanism has been studied.•Easy access of biologically important pyrazo...

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Bibliographic Details
Published in:Journal of molecular catalysis. B, Enzymatic Enzymatic, 2015-11, Vol.121, p.75-81
Main Authors: Mane, Ananda, Salokhe, Prabha, More, Pallavi, Salunkhe, Rajashri
Format: Article
Language:English
Subjects:
Aqueous medium
Baker's yeast
Biocatalysis
Pyrazoles
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Summary:•This is the first eco-efficient report for the synthesis of title compounds using biocatalysis.•Synthesis of pyrazole structural motifs expedited by fermenting baker's yeast.•The role of baker's yeast in the reaction mechanism has been studied.•Easy access of biologically important pyrazole structural cores from less reactive hydrazines and hydrazides. An expeditious oxidative cyclocondensation reaction of hydrazines/hydrazides with 1,3-dicarbonyl compound was efficiently developed in aqueous medium using Saccharomyces cerevisae (baker's yeast) as a whole cell biocatalyst at room temperature. The method has been assigned using green chemistry measures and found to give a range of N-substituted pyrazoles with moderate to excellent yields (70–92%). The reaction progress was monitored by gas chromatography.
ISSN:1381-1177
1873-3158
DOI:10.1016/j.molcatb.2015.05.020