Cross presentation from live cells

Antigens (Ag) from apoptotic HIV-infected cells can be cross-presented by human plasmacytoid dendritic cells (pDC) to CD8+ T cells1. Antigens from live cells can also be cross-presented by human monocyte-derived DC2 or by murine bone-marrow-derived DC3. We wondered whether DC isolated from human blo...

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Bibliographic Details
Published in:Molecular immunology 2022-10, Vol.150, p.34
Main Authors: Isnard, S., Hatton, E.X., Guillerme, J-B., Hosmalin, A.
Format: Article
Language:English
Online Access:Get full text
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Summary:Antigens (Ag) from apoptotic HIV-infected cells can be cross-presented by human plasmacytoid dendritic cells (pDC) to CD8+ T cells1. Antigens from live cells can also be cross-presented by human monocyte-derived DC2 or by murine bone-marrow-derived DC3. We wondered whether DC isolated from human blood were able to cross-present antigens from live cells. We will present our results on cross-presentation from live infected cells. Our aim is to understand how to stimulate different types of DC to induce presentation of cellular antigens from HIV-1 reservoirs to cytotoxic CD8+T lymphocytes, in order to decrease the size of these reservoirs during antiretroviral therapy.
ISSN:0161-5890
1872-9142
DOI:10.1016/j.molimm.2022.05.114