Oxalic acid dihydrate and proline based low transition temperature mixture: An efficient synthesis of spiro [diindenopyridine-indoline] triones derivatives

The new facile approach has been developed for the synthesis of spiro [diindenopyridine-indoline] triones under the umbrella of green chemistry. The developed protocol is endowed with the use of low transition temperature mixture as a green reaction medium, operational simplicity, easy workup proced...

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Bibliographic Details
Published in:Journal of molecular liquids 2016-07, Vol.219, p.573-578
Main Authors: Chandam, Dattatray R., Mulik, Abhijeet G., Patil, Dayanand R., Patravale, Ajinkya P., Kumbhar, Digambar R., Deshmukh, Madhukar B.
Format: Article
Language:English
Subjects:
Indenone fused heterocycles
Isatin
Low transition temperature mixture
Spiro compounds
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Summary:The new facile approach has been developed for the synthesis of spiro [diindenopyridine-indoline] triones under the umbrella of green chemistry. The developed protocol is endowed with the use of low transition temperature mixture as a green reaction medium, operational simplicity, easy workup procedures, good to excellent product yields, and non-chromatographic purification procedure. Since indenone fused motifs have a broad spectrum of biological activities, this protocol is expected to find application in the combinatorial synthesis of biologically active compounds. [Display omitted] •Low transition temperature mixture (LTTM) as a reaction promoting medium.•100% atom efficient preparation of oxalic acid dihydrate: proline LTTM.•Products with excellent yield, shorter reaction time, high atom economy.•Non-chromatographic purification protocol with mild reaction condition.•Recyclable LTTM.
ISSN:0167-7322
1873-3166
DOI:10.1016/j.molliq.2016.02.101