Enhanced prevention of progression of non alcoholic fatty liver to steatohepatitis by incorporating pumpkin seed oil in nanoemulsions

Nanoemulsions (NEs) possess several advantages and have applications in controlled drug delivery and targeting. Pumpkin seed oil (PSO) oral NEs were dispensed with the objective of improving its oral bioavailability and prolonging its therapeutic efficacy. Phase diagrams were constructed. Eighteen f...

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Bibliographic Details
Published in:Journal of molecular liquids 2017-01, Vol.225, p.822-832
Main Authors: Al-Okbi, Sahar Youssef, Mohamed, Doha Abdou, Hamed, Thanaa El-Sayed, Kassem, Ahmed Alaa, El-Alim, Sameh Hosam Abd, Mostafa, Dina Mahmoud
Format: Article
Language:English
Subjects:
Food nanotechnology
Non-alcoholic steatohepatitis
Nutraceuticals
Oral nanoemulsions
Percolation phenomenon
Pumpkin seed oil
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Summary:Nanoemulsions (NEs) possess several advantages and have applications in controlled drug delivery and targeting. Pumpkin seed oil (PSO) oral NEs were dispensed with the objective of improving its oral bioavailability and prolonging its therapeutic efficacy. Phase diagrams were constructed. Eighteen formulations were selected from Labrafac™ PG phase diagrams. They passed thermodynamic stability tests and 10 out of them passed dispersibility tests in distilled water and 0.1N HCl. Four formulations were compatible with PSO and showed total phenolic content ranging from 5.71 to 6.51mg/kg of the incorporated PSO, expressed as gallic acid equivalent (GAE). The selected formulations revealed percolative electric conductivity, physiologically compatible pH, globule size
ISSN:0167-7322
1873-3166
DOI:10.1016/j.molliq.2016.10.138