Multicomponent domino reactions in deep eutectic solvent: An efficient strategy to synthesize multisubstituted cyclohexa-1,3-dienamines

The multicomponent domino reactions of ketones, aldehydes and malononitrile in a deep eutectic solvent (DES) were developed. Urea-choline chloride based DES is effective dual solvents/organocatalysts and affording a series of multisubstituted cyclohexa-1,3-dienamines in good to excellent yields unde...

Full description

Saved in:
Bibliographic Details
Published in:Journal of molecular liquids 2017-11, Vol.246, p.221-224
Main Authors: Azizi, Najmedin, Ahooie, Tahereh Soleymani, Hashemi, Mohammad Mahmoudi
Format: Article
Language:English
Subjects:
Deep eutectic solvent
Green chemistry
Multicomponent domino reactions
Multisubstituted cyclohexa-1,3-dienamines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The multicomponent domino reactions of ketones, aldehydes and malononitrile in a deep eutectic solvent (DES) were developed. Urea-choline chloride based DES is effective dual solvents/organocatalysts and affording a series of multisubstituted cyclohexa-1,3-dienamines in good to excellent yields under mild conditions. The DES could be easily recycled several times without appreciable loss of activity. The present protocol offers advantages in terms of environmental sustainability and efficient utilization of natural resources, operational simplicity and short reaction times. [Display omitted] •Greener strategy under operational simplicity was reported.•Good to excellent yields of the products.•This approach eliminates the use of hazardous organic solvents and toxic catalysts.•Biorenewable and recyclable solvent
ISSN:0167-7322
1873-3166
DOI:10.1016/j.molliq.2017.09.049