Bovine serum albumin: An efficient biomacromolecule nanocarrier for improving the therapeutic efficacy of chrysin

• Published in: Journal of molecular liquids 2018-12, Vol.271, p.639-646
• Main Authors: Nosrati, Hamed, Rakhshbahar, Akram, Salehiabar, Marziyeh, Afroogh, Saeed, Kheiri Manjili, Hamidreza, Danafar, Hossein, Davaran, Soodabeh
• Format: Article
• Language: English
• Subjects: Albumin; BSA; Cancer; Chrysin; Drug delivery; Protein
• ISSN: 0167-7322; 1873-3166
• DOI: 10.1016/j.molliq.2018.06.066

This study manipulated a chrysin loaded bovine serum albumin nanoparticles (BSA NPs), which could solubilize the poorly water-soluble drug and increase the therapeutic efficacy of the drug. Chrysin (5, 7-dihydroxyflavone) is a natural flavonoid which have some significant biological effects on the processes of chemical defense. Chrysin loaded bovine serum albumin nanoparticles (Chrysin-BSA NPs) were synthesized by a simple desolvation procedure. The resultant Chrysin-BSA NPs showed a spherical shape, with a diameter of 97.5 ± 5.75 nm (mean ± SD) nm and a ζ-potential of - 11 mV. The in vitro drug release study of chrysin presented a sustained and controlled release pattern. Cellular toxicity of BSA NPs was also investigated on HFF2 cell lines. Additionally, a hemolysis test of as prepared NPs were performed. Hemolysis assay and cytotoxicity study results on HFF-2 cell line show that as prepared BSA NPs are biocompatible. The in vitro cytotoxicity of the nanoparticles was performed by MTT assay on MCF-7 cancer cells. These results suggest that Chrysin-BSA NPs are a new drug delivery system for cancer therapy. [Display omitted] •The bovine serum albumin nanoparticles were prepared through desolvation process.•The resultant Chrysin-BSA NPs showed a spherical shape, with a diameter of 97.5 ± 5.75 nm.•Hemolysis assay and cytotoxicity study results show that BSA NPs are biocompatible. Therefore, the prepared Chrysin-BSA NPs is a promising drug delivery system for chrysin.