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Blood optical absorption of rats with hepatic damage and turmeric treatment: Methemoglobin analysis
Photoacoustic spectroscopy (PAS) is singled out by its capability to resolve the optical absorption spectra of each element, of a multicomponent system, by the named phase resolved method. The possibility of the use of this method is due to the fact that the Photoacoustic signal is not only sensitiv...
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Published in: | Journal of molecular liquids 2019-10, Vol.291, p.111310, Article 111310 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Photoacoustic spectroscopy (PAS) is singled out by its capability to resolve the optical absorption spectra of each element, of a multicomponent system, by the named phase resolved method. The possibility of the use of this method is due to the fact that the Photoacoustic signal is not only sensitive to the optical absorption of the sample as well as the non-radiative relaxation times of its elements. In the present study we compare and analyze, by phase resolved method, Fisher rat blood in four groups: healthy rat blood, liver cancer rat blood, healthy rat blood given by a daily dose of Curcuma longa, and liver cancer rat blood given by a daily dose of Curcuma longa (turmeric), where the optical absorption spectra of the analyzed blood samples was obtained by PAS, in a wavelength range from 350 nm to 650 nm. Three repetitions of 60 μl of blood for each group was done. By using the phase resolved method a new optical absorption band suggestive of methemoglobin was found, observing the benefits of the intake of turmeric due to the fact that the optical absorption spectrum of the Cancer + turmeric group diminish 14% with respect to the Cancer group, anticipating a lower concentration of methemoglobin in blood.
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•PAS detect differences in non-radiative relaxation times in blood components.•PRM revealed an absorption band possibly related to methemoglobin in blood samples.•Therapeutic effect of turmeric is observed through the absorption spectra of blood. |
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ISSN: | 0167-7322 1873-3166 |
DOI: | 10.1016/j.molliq.2019.111310 |