Synthesis of nanoencapsulated vitamin E in phase change material (PCM) shell as thermo-sensitive drug delivery purpose

• Published in: Journal of molecular liquids 2020-12, Vol.320, p.114429, Article 114429
• Main Authors: Mohammadi, Behrouz, Shekaari, Hemayat, Zafarani-Moattar, Mohammed Taghi
• Format: Article
• Language: English
• Subjects: Drug delivery; Nanoencapsulation; Phase change materials; Thermo-sensitive; Vitamin E; α-Tocopherol
• ISSN: 0167-7322; 1873-3166
• DOI: 10.1016/j.molliq.2020.114429

Purpose of this paper is preparation of nanoencapsulated vitamin E (α-tocopherol) in phase change material (PCM) shell for thermo-sensitive drug delivery purpose. This type of enloaded nanoencapsules with vitamin E have not been reported in literature, nor patented. Vitamin E has been successfully nanoencapsulated in stearic acid-lauric acid (SA-LA) eutectic mixture with (1:3) mole ratio in the form of core-shell structure for thermo-sensitive drug delivery purpose. The obtained results from FT-IR spectrum and SEM nanographs indicate the success of encapsulation process to create core-shell structure with spherical shape. The particle size distribution (PSD) measurement shows a 70–550 nm size distribution which is in the range of nanoencapsulated products. The measured zeta potential for the nanoencapsules indicates good stability in suspension during 120 days. Thermogravimetric analysis (TGA) test supply drug to PCM ratio with (65:35) wt% which is in good agreement with that used in the recipe. The obtained results indicate the high efficiency of used method for nanoencapsulation of vitamin E (α-tocopherol) in PCM shell. At last, the result of releasing test for the nanocapsules shows the rapid and easy release of vitamin E from the synthesized nanoencapsules at T = 37 °C. [Display omitted] •Purpose of this paper is nanoencapsulation of vitamin E in thermo-sensitive shell.•Vitamin E is nanoencapsulated in phase change material shell, successfully.•The particle size distribution is between (70–550) nm for nanocapsules.•Thermogravimetric analysis (TGA) confirms drug to PCM ratio with (65:35) wt%.