Comparative study of surface-active and biological properties of lactose-derived acylhydrazones

In this study, we report the first preparation of a series of lactose-derived acylhydrazone compounds with alkyl side chains ranging from 5 to 10 carbons in length through condensation reactions as a new type of nonionic surfactants. The surface-active, foaming properties, emulsifying properties, th...

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Bibliographic Details
Published in:Journal of molecular liquids 2021-01, Vol.322, p.114989, Article 114989
Main Authors: Zhang, Shixin, Li, Yusi, Han, Maochun, Wu, Yao, Hu, Lei
Format: Article
Language:English
Subjects:
Acylhydrazones
Biological activities
Emulsifying properties
Surfactant properties
Thermal stabilities
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Summary:In this study, we report the first preparation of a series of lactose-derived acylhydrazone compounds with alkyl side chains ranging from 5 to 10 carbons in length through condensation reactions as a new type of nonionic surfactants. The surface-active, foaming properties, emulsifying properties, thermal stability as well as cytotoxicity were studied to establish the structure-property profile, which revealed that the acylhydrazone derivatives bearing medium-length side chains had better overall performance than their analogs and other selected commercial references. The results could serve as basis for the further development of lactose-derived acylhydrazones as emulsifiers in, for example, food and pharmaceutical industries. •Novel lactose-derived acylhydrazones were designed and synthesized as emulsifiers.•Structure-property profiles, including cytotoxicity, were established.•Medium-sized acylhydrazones performed better than other analogs and selected commercial references.
ISSN:0167-7322
1873-3166
DOI:10.1016/j.molliq.2020.114989