Synthesis of ruthenium doped titanium dioxide nanoparticles for the electrochemical detection of diclofenac sodium

• Published in: Journal of molecular liquids 2021-10, Vol.340, p.116891, Article 116891
• Main Authors: Killedar, Laxmi, Ilager, Davalasab, Shetti, Nagaraj P., Aminabhavi, Tejraj M., Raghava Reddy, Kakarla
• Format: Article
• Language: English
• Subjects: Cyclic voltammetry; Diclofenac sodium; Doped TiO2 nanoparticles; Electrochemical sensor; Healthcare
• ISSN: 0167-7322; 1873-3166
• DOI: 10.1016/j.molliq.2021.116891

[Display omitted] •Ru-doped TiO2 (Ru-TiO2) nanoparticles were synthesized by facile chemical method.•Ru-TiO2 NPs used for electrochemical sensing of diclofenac sodium (DFS)•Electro-oxidation involves two electrons and protons with diffusion controlled process.•High sensitivity with a detection limit of 1.48 nM of DFS.•Prototype developed was employed to assay DFS in clinical and pharmaceutical samples. In this work, ruthenium-doped titanium dioxide (Ru-TiO2) modified electrochemical sensor was developed for the determination of nonsteroidal anti-inflammatory drug, such as diclofenac sodium (DFS) using a voltammetric technique. Ru-TiO2 nanoparticles were characterized using SEM, TEM, EDX, and XRD techniques. It was found that sensitivity and selectivity of the Ru-TiO2 based sensor were enhanced. The pH study revealed that pH 4.2 was found to be suitable to improve the electrochemical behaviour of DFS. The electro-oxidation of DFS was irreversible and predominantly controlled by the diffusion process. The square wave voltammetric technique was also used and the detection limit (LOD) obtained was 1.48 nM, which is smaller than the previously reported data. The suggested approach is suggested for both quality assurance and effectively determining DFS in biological and clinical samples.