Lipid shell lipid nanocapsules as smart generation lipid nanocarriers

• Published in: Journal of molecular liquids 2021-10, Vol.339, p.117145, Article 117145
• Main Authors: Dabholkar, Neha, Waghule, Tejashree, Krishna Rapalli, Vamshi, Gorantla, Srividya, Alexander, Amit, Narayan Saha, Ranendra, Singhvi, Gautam
• Format: Article
• Language: English
• Subjects: Lipid nanocapsules; lipid-based nanocarriers; nanocapsules; Phase inversion temperature; smart generation lipid nanocarriers
• ISSN: 0167-7322; 1873-3166
• DOI: 10.1016/j.molliq.2021.117145

[Display omitted] •LNCs contain oily core, an external shell made of solid lipid and emulsifying agent.•LNCs are prepared using phase inversion process.•LNCs are biodegradable and have small size (20–100 nm)•LNCs provide higher entrapment of lipophilic drugs and possess physical stability. Lipid nanocapsules (LNCs) are lipid-based nanocarriers that have found application as drug delivery systems, in diagnostics, and theranostics. They are biocompatible and able to circumvent biological membranes easily because of their morphological features and structural facets. This article aims to review lipid shell lipid nanocapsules as a smart generation of lipid nanocarriers. These nanocapsules are prepared by the method of phase inversion temperature because of low energy consumption and easy scale-up. Further, the composition, method of preparation, the effect of surface modification of LNCs, medical/biomedical applications, and patents have been described with the help of reported studies. In the end, an attempt has been made to understand the future prospects of employing LNCs as delivery systems. This review will provide a unique perspective to the readers, and help them in empathizing with the far-reaching implications of LNCs as smart generation of lipid nanocarriers.