Effect of interfacially-engineered nanoemulsions of linoleic acid stabilized by mixed surfactant systems and curcumin on their physicochemical properties, induction times, and peroxidation stability

• Published in: Journal of molecular liquids 2023-08, Vol.384, p.122243, Article 122243
• Main Authors: Kour, Pawandeep, Ahmad Dar, Aijaz
• Format: Article
• Language: English
• Subjects: Antioxidant; Bioavailability; Oxidative stability; Peroxidation; Shelf-life
• ISSN: 0167-7322; 1873-3166
• DOI: 10.1016/j.molliq.2023.122243

[Display omitted] •Interfacially-engineered nanoemulsions using mixed surfactants were prepared.•The interfacial H+ ion concentration determined kobs values.•Curcumin stability depended on its solubilization, interfacial pH and surfactant used.•Peroxidation of linoleic acid in nanoemulsions was inhibited. Nanoemulsions have become the best candidates for loading hydrophobic bioactive molecules and enhancing their shelf-life and bioavailability in the food, pharmaceutical and cosmetic industries. Mixture of different surfactants modulates their interfacial characteristics, thereby imposing a direct effect in improving their physicochemical and nutritional characteristics. Herein, we report the formulation of oil-in-water nanoemulsions stabilized with either single or mixture of surfactants having different electric charges like Tween 20 (T20, nonionic), sodium salt of Lauroyl Sarcosine (LS, anionic) and 3-(N,N-dimethylmyristylammonio)propanesulfonate (DPS, zwitterionic) to control the peroxidation of linoleic acid by using curcumin as the potential antioxidant. The distribution of H+ ions at the interface and the variation in the values of observed rate constant (kobs) is assessed by employing the novel Chemical Kinetic method based on the reaction between arenediazonium ions and the antioxidant. For single-surfactant systems, nanoemulsions containing pure T20 or LS showed good oxidative stability whereas for mixed-surfactant systems, the oxidative stability increases with increasing concentration of LS and decreasing concentration of DPS. This could be explained on the basis of physicochemical characterization of nanoemulsions, interfacial H+ ion concentration, and solubility characteristics of curcumin. The study shows great promise of such mixed surfactant systems, ignored so far, for providing a novel and tailored formulation of nanoemulsions for improving the oxidative stability of linoleic acid.