Stimuli-responsive nanogels: A smart material for biomedical applications

• Published in: Journal of molecular liquids 2024-06, Vol.403, p.124828, Article 124828
• Main Authors: Chakroborty, Subhendu, Nath, Nibedita, Mahal, Ahmed, Barik, Arundhati, Panda, Amiya Ranjan, Fahaduddin, Bal, Trishna, Obaidullah, Ahmad J., Elawady, Ahmed
• Format: Article
• Language: English
• Subjects: Drug delivery; Nanogels; Stimuli-responsive nanogels (SRNGs); Tissue engineering; Wound healing
• ISSN: 0167-7322
• DOI: 10.1016/j.molliq.2024.124828

•The most current developments in stimuli-responsive nanogels (SRNGs) are covered in this review.•The Biomedical applications of SRNGs are also discussed.•The discussion of various synthesis and characterization techniques are also highlighted. Nanogels (NGs) are gaining recognition as very promising platforms for many biological applications owing to their unique characteristics, such as small size, remarkable water retention capacities, and customizable properties. Compared to traditional and micro-sized delivery, NGs are more productive. In the realm of biotechnology, nanogels have been widely utilized in recent years to address protein synthesis, enzyme immobilization, and genetics. Additionally, it is a valuable asset for the creation of innovative medical treatment systems. These are soft materials having the ability to encapsulate pharmaceuticals, inorganic nanoparticles, and tiny molecular biomacromolecules within their crosslinked networks. This property enables the materials to be used for both imaging and treatment of a wide range of medical problems. These characteristics not only improve the carrier system's performance but also aid in resolving a number of issues related to the delivery of cargo molecules.. The phenomenon of stimuli-responsive nanogels (SRNGs) has garnered considerable attention because to its ability to undergo reversible alterations in response to specific stimuli, regardless of whether they originate from natural sources or external factors. This study investigates the methodologies employed in the production of SRNGs and their utilization in the realm of biomedicine, particularly focusing on their application in tissue engineering, drug administration, genetic treatment, and wound healing.