A review on exploring the impact of graphene oxide-based nanomaterials on structures and bioactivity of proteins

•Mechanism of formation and kinetics of nano protein corona.•Several methodologies for analyzing the protein corona.•Various factors affecting the formation of protein corona.•Effect of GO and GBN on conformation of different proteins.•Cytotoxic effects of GO and GBN on different cell lines. In the...

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Bibliographic Details
Published in:Journal of molecular liquids 2024-06, Vol.404, p.124980, Article 124980
Main Authors: Sharma, Navita, Yadav, Deepika, Hassan, Md. Imtaiyaz, Srivastava, Chandra Mohan, Majumder, Sudip
Format: Article
Language:English
Subjects:
Drug delivery
Graphene oxide nanocomposites
Nano-carrier
Nano-protein corona
Protein conformation
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Summary:•Mechanism of formation and kinetics of nano protein corona.•Several methodologies for analyzing the protein corona.•Various factors affecting the formation of protein corona.•Effect of GO and GBN on conformation of different proteins.•Cytotoxic effects of GO and GBN on different cell lines. In the past few decades, graphene oxide-based nanomaterials (GBN) have been utilized for various biomedical applications, including tissue engineering, drug delivery, biosensors, and regenerative medicines. However, the interaction of graphene oxide (GO) and its nanocomposites with various cellular biomolecules like protein is not fully explored. Once the nanoparticles (NPs) enter the biological environment, they are surrounded by various biological fluids that form a complex between biomolecule and NP. The complex is commonly known as “nano-protein corona” (PC). The behavior of nano-PC is influenced by various factors such as size, shape, pH, temperature, porosity, hydrophilicity, surface charge, and roughness of the nanomaterial. Analyzing the effect of multiple nanomaterial properties on the nano-PC is crucial for bio-nano-interface studies. In this review, we summarize the interaction of various proteins with GO and its nanocomposites, GBN in biophysical studies and bio-reactivity. In this review, we mainly depict the nature of GBN-PC, its significance, and its kinetics. In addition, factors affecting the nano protein-corona and the analytical techniques utilized to study the nature of nano-PC have also been discussed.
ISSN:0167-7322
1873-3166
DOI:10.1016/j.molliq.2024.124980