Synthesis, characterization, spectroscopic studies and antimicrobial activity of three new Schiff bases derived from Heterocyclic moiety

Three new Schiff-bases compounds (I-III) were synthesized by a condensation reaction in 1:2 M ratios of 4,4′-diaminodiphenyl sulfide and pyrrol/thiophene/furan-2-carboxaldehyde in ethanol. The structural determinations of the Schiff-bases were identified with the help of elemental analysis then conf...

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Bibliographic Details
Published in:Journal of molecular structure 2018-01, Vol.1151, p.41-48
Main Authors: Mesbah, Mounira, Douadi, Tahar, Sahli, Farida, Issaadi, Saifi, Boukazoula, Soraya, Chafaa, Salah
Format: Article
Language:English
Subjects:
4,4′-diaminodiphenyl sulfide
Antibacterial activity
Antifungal activity
Heterocyclic aldehydes
Schiff bases
Spectral studies
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Summary:Three new Schiff-bases compounds (I-III) were synthesized by a condensation reaction in 1:2 M ratios of 4,4′-diaminodiphenyl sulfide and pyrrol/thiophene/furan-2-carboxaldehyde in ethanol. The structural determinations of the Schiff-bases were identified with the help of elemental analysis then confirmed by UV–Vis, FT-IR and 1H NMR. The products were obtained in excellent yields. On the other hand, the in vitro antibacterial and antifungal activities of the synthesized compounds were investigated using disc diffusion method. Schiff bases synthesized individually exhibited varying degrees of inhibitory effects on the growth of the tested microbial species. [Display omitted] •Synthesis of three new heterocyclic Schiff bases.•Characterization of synthesized Schiff bases by the elemental analyses and different spectral studies.•The Antimicrobial study revealed that the synthesized Schiff base showed better activity antifungal than antibacterial.
ISSN:0022-2860
1872-8014
DOI:10.1016/j.molstruc.2017.08.098