EPR investigation of damage centers formed in some drug powders irradiated with gamma rays

The radiation damage centers in levetiracetam, progesterone, ethosuximide, and propranolol hydrochloride were investigated by EPR spectroscopy at 295 K. The paramagnetic species were attributed to the -ĊHCHNH-, -CH2ĊH2CH- and -ĊH-, -ĊHCH2N- and-ĊH-, and -NĊCH2- radicals, respectively. The results we...

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Bibliographic Details
Published in:Journal of molecular structure 2018-07, Vol.1163, p.1-3
Main Author: Sütçü, Kerem
Format: Article
Language:English
Subjects:
Drugs
EPR
Free radicals
γ-irradiation
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Summary:The radiation damage centers in levetiracetam, progesterone, ethosuximide, and propranolol hydrochloride were investigated by EPR spectroscopy at 295 K. The paramagnetic species were attributed to the -ĊHCHNH-, -CH2ĊH2CH- and -ĊH-, -ĊHCH2N- and-ĊH-, and -NĊCH2- radicals, respectively. The results were observed as being in good conformity with the literature. The spectra of these compounds were computer simulated. Furthermore, the EPR parameters of the radicals formed by ɣ-irradiation in the samples were determined. [Display omitted] •Four drug powders were investigated by EPR spectroscopy.•The spectra of the compounds were computer simulated.•The EPR parameters and the structure of the radicals were identified.
ISSN:0022-2860
1872-8014
DOI:10.1016/j.molstruc.2018.02.101