Synthesis of novel Azol-β-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their molecular docking studies

This study reports the synthesis, biological investigation and molecular docking of novel β-lactam derivatives bearing 1,3,4-thiadiazole and 1,3,4-oxadiazole ring system. The synthesized compounds were evaluated for in vitro antiurease activity and antioxidant capacity. Almost all compounds showed e...

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Bibliographic Details
Published in:Journal of molecular structure 2019-08, Vol.1189, p.279-287
Main Authors: Mermer, Arif, Bayrak, Hacer, Şirin, Yakup, Emirik, Mustafa, Demirbaş, Neslihan
Format: Article
Language:English
Subjects:
Antioxidant capacity
Antiurease activity
Azole
Molecular docking
Phenyl piperazine
β-Lactam
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Summary:This study reports the synthesis, biological investigation and molecular docking of novel β-lactam derivatives bearing 1,3,4-thiadiazole and 1,3,4-oxadiazole ring system. The synthesized compounds were evaluated for in vitro antiurease activity and antioxidant capacity. Almost all compounds showed excellent antiurease activity compared to thiourea, standard drug. Also, in silico ADME (absorption, distribution, metabolism, elimination) prediction and molecular docking studies were performed.
ISSN:0022-2860
1872-8014
DOI:10.1016/j.molstruc.2019.04.039