Synthesis, characterization and Al3+ sensing application of a new chromo-fluorogenic chemosensor

• Published in: Journal of molecular structure 2019-10, Vol.1193, p.69-75
• Main Authors: Leng, Xin, Jia, Xu, Qiao, Chengfang, Xu, Wenfeng, Ren, Chongting, Long, Ying, Yang, Bingqin
• Format: Article
• Language: English
• Subjects: Al3+ detection; Bioimaging; Fluorescence probe; Rhodamine derivative
• ISSN: 0022-2860; 1872-8014
• DOI: 10.1016/j.molstruc.2019.05.032

A rhodamine B-based chromo-fluorogenic probe BOS is prepared with a good yield by condensating an o-diaminobenzene functionalized rhodamine derivative (RBO) and a large steric hindrance salicylaldehyde, and characterized by elemental analysis, infrared spectroscopy (IR), 1H and 13C NMR technology, and high resolution mass spectrum (HRMS). Spectroscopy experiments reveal that the probe can selectively and sensitively detect Al3+ from a variety of metal ions with a low detection limit of 1.855 μmol/L. Compared to traditional detection methods, BOS provides an inexpensive, rapid and straightforward way for Al3+ detection that can be distinguished by “naked eye”. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2-H- tetrazoliubromide) assays and cell imaging experiments demonstrate that the sensor is low toxic and amicable for Al3+ sensing in living cells. [Display omitted] •A novel rhodamine-based probe BOS is designed and synthesized.•BOS is able to high selectively and sensitively detect Al3+.•The detection process can be identified through naked eye.•BOS is capable of detecting Al3+ in complex biological environment.