A new fluorescent probe based on imidazole[2,1-b]benzothiazole for sensitive and selective detection of Cu2

• Published in: Journal of molecular structure 2020-03, Vol.1203, p.127384, Article 127384
• Main Authors: Wang, Hanyu, Zhao, Songfang, Xu, Yuankang, Li, Linlin, Li, Bing, Pei, Meishan, Zhang, Guangyou
• Format: Article
• Language: English
• Subjects: Benzothiazole derivative; Cu2; DFT; Fluorescent probe; PET
• ISSN: 0022-2860; 1872-8014
• DOI: 10.1016/j.molstruc.2019.127384

A simple fluorescent chemosensor WS1 (N'-[(Z)-1H-indazol-3-ylmethylidene]imidazo [2,1-b] [1,3]benzothiazole-2-carbohydrazide) based on imidazole [2,1-b]benzothiazole was designed and synthesized. The probe showed specific recognition towards Cu2+ through colorimetric and “turn-off” fluorescence response in MeOH/H2O (9:1 V/V) buffer solution (10 mM Tris, pH = 7.4) with detection limit of 4.32 × 10−8 M. In addition, WS1 was a reversible fluorescence probe for the detection of Cu2+, the fluorescence intensity recovered to the similar state of free WS1 as PPi was added. And it showed a favorable potency for actual water monitoring. The proposed binding mode of WS1 with Cu2+ was verified by DFT calculation using Gaussian 09. •The probe showed specific recognition towards Cu2+ through colorimetric and fluorescence response.•The LOD for Cu2+ were 4.63 × 10−7 M and 4.32 × 10−8 M by colorimetric and fluorescence response, respectively.•The proposed binding mode of WS1 with Cu2+ was verified by DFT calculation.•WS1 can detect Cu2+ in tap water samples with acceptable recovery and RSD.