Synthesis, crystal structure study, and antimicrobial evaluation activity of aryl-substituted dihydroisoquinoline oxaziridine

Models of dihydroisoquinoline oxaziridines substituted in position 1 were synthesized from the peracidic oxidation of imines and characterized through the IR, elemental analysis and NMR spectral studies; the crystal structure of 3d was determined from single crystal X-ray diffraction data. All these...

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Bibliographic Details
Published in:Journal of molecular structure 2020-04, Vol.1205, p.127592, Article 127592
Main Authors: Falah, Samah, Abdmouleh, Fatma, Aydi, Rihab, Hamdi, Besma, El Arbi, Mehdi, Kammoun, Majed
Format: Article
Language:English
Subjects:
Antimicrobial activity
Imines
Oxaziridines
X-ray structure
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Summary:Models of dihydroisoquinoline oxaziridines substituted in position 1 were synthesized from the peracidic oxidation of imines and characterized through the IR, elemental analysis and NMR spectral studies; the crystal structure of 3d was determined from single crystal X-ray diffraction data. All these compounds were evaluated for their antimicrobial activity. [Display omitted] •Synthesis and Characterization studies of four dihydroisoquinoline oxaziridines.•Structure of compound 3d was established by Single X-ray crystallography.•In vitro antimicrobial screening were studied.•The significant biological effect of the presence of nitro group in this class of compounds.
ISSN:0022-2860
1872-8014
DOI:10.1016/j.molstruc.2019.127592