A novel schiff base ligand and its copper complex: Synthesis, characterization, X-ray crystal structure and biological evaluation

• Published in: Journal of molecular structure 2021-02, Vol.1226, p.129395, Article 129395
• Main Authors: Kondori, Tahere, Akbarzadeh-T, Niloufar, Fazli, Mahboubeh, Mir, Behrouz, Dušek, Michal, Eigner, Václav
• Format: Article
• Language: English
• Subjects: Antibacterial activity; Disc diffusion; Gram negative; Schiff base ligand; X-ray crystallography
• ISSN: 0022-2860; 1872-8014
• DOI: 10.1016/j.molstruc.2020.129395

•The novel schiff base ligand of(a) crystallized in monoclinic system, in centrosymmetric space group P21/cand complex (b) crystallized in triclinic system, in centrosymmetric space group P-1.•The antibacterial activities have been studied in-vitro against two gram-negative (Escherichiacoli and pseudomonas aeruginosa) and two gram positive (Staphylococcus aureus and enterococcus faecalis) standard bacterial strains.•The complex (b) was a stronger antibacterial agent than the free ligand (a). A novel Schiff base ligand of (4-nitroaniline-2-hydroxybenzaldehyde) (a) and its complex [Cu(4-nitroaniline-2-hydroxybenzaldehyde)2] (b) were synthesized and characterized by FT-IR, UV–Vis spectroscopy, elemental analysis and X-ray crystallography.The antibacterial activities have been studied in-vitro against two gram-negative (E. coliandPseudomonas aeruginosa) and two gram positive (Staphylococcus aureus and Enterococcus faecalis)standard bacterial strains. The ligand and its metal chelate were screened for their antimicrobial activities using the disk diffusion method against the selected bacteria. The complex (b) was a stronger antibacterial agent than the free ligand as well as its corresponding metal salt, and it was more active against the gram-positive than gram-negative bacteria.