Synthesis, structure and fungicidal activity of some new threoninamide carbamate derivatives

•The new threoninamide carbamate derivatives were designed and synthesized.•The structures were confirmed by NMR, MS and single crystal diffraction.•The fungicidal activity against Oomycete fungi Phytophthora capsici were examined in vivo and in vitro.•The structure-activity relationship was studied...

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Bibliographic Details
Published in:Journal of molecular structure 2021-03, Vol.1227, p.129398, Article 129398
Main Authors: Du, Xiu-Jiang, Peng, Xing-Jie, Zhao, Rui-Qi, Zhao, Wei-Guang, Liu, Xing-Hai, Dong, Wei-Li
Format: Article
Language:English
Subjects:
Fungicidal activity
Reaction
SAR
Synthesis
Threoninamide carbamate compounds
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Summary:•The new threoninamide carbamate derivatives were designed and synthesized.•The structures were confirmed by NMR, MS and single crystal diffraction.•The fungicidal activity against Oomycete fungi Phytophthora capsici were examined in vivo and in vitro.•The structure-activity relationship was studied. In order to find new CAA fungicides, twenty four new threoninamide carbamate derivatives were synthesized. The reaction was optimized. Their structures were confirmed by 1H NMR, 13C NMR, single crystal and HRFTMS. Fungicidal activities were evaluated against P. capsici and P. cubensi. All of them exhibited excellent activity against Phytophthora capsici in vitro with EC50 values of 0.53 to 20.17 μg/mL. Notably, compounds 3-11, 3-19 and 3-20 possessed good control effect(>70%) against P. capsici in vivo at 6.25 μg/mL.
ISSN:0022-2860
1872-8014
DOI:10.1016/j.molstruc.2020.129398