Design and synthesis of new series of dipyrromethane-coumarin and porphyrin-coumarin derivatives: Excellent anticancer agents

•Anticancer drugs have achieved great successes in recent years.•Designed and synthesized dipyrromethane-coumarin and porphyrin-coumarin Derivatives.•Dipyrromethane-coumarins and porphyrin-coumarins were screened for their anticancer activity at NCI-USA.•Among the synthesized series, two compounds w...

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Bibliographic Details
Published in:Journal of molecular structure 2021-08, Vol.1237, p.130424, Article 130424
Main Authors: Holiyachi, Megharaja, Shastri, Samundeeswari L., Chougala, Bahubali M., Naik, Nirmala S., Pawar, Varsha, Shastri, Lokesh A., Joshi, Shrinivas D., Sunagar, Vinay A.
Format: Article
Language:English
Subjects:
Anticancer 4-Formylcoumarins
ct-DNA interaction
Dipyrromethane
Molecular docking
Porphyrin-coumarin
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Summary:•Anticancer drugs have achieved great successes in recent years.•Designed and synthesized dipyrromethane-coumarin and porphyrin-coumarin Derivatives.•Dipyrromethane-coumarins and porphyrin-coumarins were screened for their anticancer activity at NCI-USA.•Among the synthesized series, two compounds were referred three time repeat analysis and three time recommended to Biological evaluation committee (BEC) in NCI. These two compounds are most prominent anticancer agents with GI50 values
ISSN:0022-2860
1872-8014
DOI:10.1016/j.molstruc.2021.130424