Ultrasonic assisted reverse micelle synthesis of a novel Zn-metal organic framework as an efficient candidate for antimicrobial activities

• Published in: Journal of molecular structure 2022-01, Vol.1247, p.131315, Article 131315
• Main Authors: Zeraati, Malihe, Moghaddam-Manesh, Mohammadreza, Khodamoradi, Sepideh, Hosseinzadegan, Sara, Golpayegani, Abdolali, Chauhan, Narendra Pal Singh, Sargazi, Ghasem
• Format: Article
• Language: English
• Subjects: Antibacterial; Antifungal; Characterization; Metal organic framework; Surface area; X-ray photo electron spectroscopy
• ISSN: 0022-2860; 1872-8014
• DOI: 10.1016/j.molstruc.2021.131315

•Zn-MOF has been prepared using ultrasonic assisted reverse micelle process.•FT-IR, XRD, XPS, SEM, EDX, nitrogen surface area and TGA were used for characterization.•It has shown reasonably good antimicrobial activities as compared to standard drugs. In this study, Zn-MOF, [Zn(dicarb)2].2H2O (H2dicarb = 2,6-pyridine dicarboxylic acid) was synthesised from zinc nitrate and 2,6-pyridine dicarboxylic acid in a 1: 1 molar ratio using an ultrasonic assisted reverse micelle process. FTIR (Fourier transform infrared spectroscopy), XPS (X-ray photo electron spectroscopy), XRD (X-ray diffractogram), FE-SEM, nitrogen adsorption surface area, TGA, and other techniques have been used to characterize the Zn-MOF. Zn-MOF has also been screened against a variety of Gram-positive and Gram-negative bacteria, as well as pathogenic fungi. Based on inhibition zone diameter (IZD), minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentration (MFC), it was ascertained that Zn-MOF is a reasonably good antimicrobial agent in comparison to some commercially available drugs. This antimicrobial Zn-MOF shows promise for use in the prevention of infections associated with medical devices. [Display omitted]