Binuclear Cu(II) complex based on N-acetylanthranilic acid induces significant cytotoxic effect on three cancer cell lines

•An anionic complex of Cu(II) with N-acetylanthranilic ligand was prepared and analyzed by single crystal X-ray diffraction.•The complex is dimeric containing a Cu-Cu bond.•The complex exerted significant cytotoxic effect on MDA-MB-231 breast cancer cells and moderate anti-proliferative activity aga...

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Bibliographic Details
Published in:Journal of molecular structure 2022-02, Vol.1249, p.131634, Article 131634
Main Authors: Aly, Aref A.M., Zidan, Amna S.A., Ibrahim, Ahmed B.M., Mosbah, Hanan K., Mayer, Peter, Saber, Saber H.
Format: Article
Language:English
Subjects:
Bladder cancer
Breast cancer
Dimeric complex
Octahedral
Prostate cancer
Single crystal
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Summary:•An anionic complex of Cu(II) with N-acetylanthranilic ligand was prepared and analyzed by single crystal X-ray diffraction.•The complex is dimeric containing a Cu-Cu bond.•The complex exerted significant cytotoxic effect on MDA-MB-231 breast cancer cells and moderate anti-proliferative activity against PC-3 prostatic and T-24 bladder cancer cells. This paper presents the isolation of single crystals of an anionic Cu(II) complex (NH4)(NHEt3)[Cu2(L)4Cl2]{HL = N-acetylanthranilic acid and NEt3= triethylamine}. The analyses revealed the complex packing in the triclinic "P-1" space group in addition to its dimeric structure and the octahedral geometry around the Cu(II)ions. In the complex, all the four carboxylate ligands are bridging the two Cu(II) centers and the charge on the anionic complex is compensated by an ammonium and protonated triethylamine ions. This Cu(II) complex is interestingly exerting highly significant cytotoxic effect on MDA-MB-231 breast cancer cells with IC50of 131.2 µg/ml and moderate anti-proliferative activity against both PC-3 prostatic cancer and T-24 transitional cell carcinoma cells with IC50 of 200.7 and 300.3 µg/ml, respectively.
ISSN:0022-2860
1872-8014
DOI:10.1016/j.molstruc.2021.131634