Synthesis, spectroscopic characterization and antimicrobial properties of silyl-tethered benzimidazolium salts

•Novel silyl-tethered benzimidazolium salts were synthesized via stepwise N-alkylation of benzimidazole.•These salts were characterized by elemental analysis, IR, 1H, 13C NMR spectroscopy.•Their antibacterial and antifungal activities were investigated.•These salts showed good antimicrobial activity...

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Bibliographic Details
Published in:Journal of molecular structure 2022-09, Vol.1264, p.133308, Article 133308
Main Authors: Yiğit, Murat, Şireci, Nihat, Günal, Selami, Önderci, Muhittin, Özdemir, Namık, Arınç, Ali, Yiğit, Beyhan, Özdemir, İsmail
Format: Article
Language:English
Subjects:
Antibacterial
Antifungal
Antimicrobial
Benzimidazolium
N-heterocyclic carbene
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Summary:•Novel silyl-tethered benzimidazolium salts were synthesized via stepwise N-alkylation of benzimidazole.•These salts were characterized by elemental analysis, IR, 1H, 13C NMR spectroscopy.•Their antibacterial and antifungal activities were investigated.•These salts showed good antimicrobial activity. A series of new silyl-substituted benzimidazolium salts were synthesized in good yield by the reaction of 1-(dimethylvinylsilyl)methylbenzimidazole and various alkyl halides. These salts were characterized by spectroscopic techniques. Also, crystal structure of 2c has been determined by the single-crystal X-ray diffraction method. Newly synthesized compounds were tested for antibacterial and antifungal activities and the minimum inhibitory concentrations were determined. The results indicates that some of compounds exert effective antibacterial activity against four Gram (-) bacterial and four Gram (+) bacterial strains and two yeast strains. [Display omitted]
ISSN:0022-2860
1872-8014
DOI:10.1016/j.molstruc.2022.133308