Facile catalytic construction of one-pot two-component 1,3,4-oxadiazole derivatives over Zn promoted Cu/CeO3 catalysts in semi-aqueous condition

• Published in: Journal of molecular structure 2023-11, Vol.1291, p.136004, Article 136004
• Main Authors: Alharthi, Abdulrahman I., Alotaibi, Mshari A., AbdelFattah, E., Akela, Mohamed A., Ali, Imtiaz, Nassar, Amal. A., Bakht, Md. Afroz
• Format: Article
• Language: English
• Subjects: 1% Zn-Cu CeO2; 1,3,4-oxadiazoles; Characterization; Semi-aqueous
• ISSN: 0022-2860; 1872-8014
• DOI: 10.1016/j.molstruc.2023.136004

•One-pot two-component 1,3,4-oxadiazole derivatives were synthesized using 1% Zn-Cu CeO2 catalyst in semi-aqueous condition.•The reaction completed with excellent in less than 1 h.•The method follows the green chemistry approach with no watste production.•The structure of recycled 1% Zn-Cu CeO2 was remain same after four consecutive cycle. Novel Zn promoted Cu/CeO3 catalysts was investigated to the green 1,3,4-oxadiazole synthesis via two component condensation of 2-aminobenzhydrazide and aldehydes in semi-aqueous environment. FT-IR, XRD, SEM, Raman, XPS, and BET have been used to examine catalyst through structural investigation. To determine the catalyst's use, some 1, 3,4-Oxadizole compounds were produced with varied catalyst concentrations in semi-aqueous circumstances. It was thoroughly investigated how pure Cerium oxide, Zinc nitrate and Copper nitrate affect the yield and reaction time of 1, 3,4-Oxadizole derivatives. The model compound under optimized condition afforded maximum yield (96%) in just 45 min. The goal of current research is to create a cheap, reusable catalyst that can be easily handled, produces a lot of products, and reacts quickly. The produced organic molecules were further examined using FT-IR and NMR techniques to identify the synthesized compounds. Furthermore, the novel catalyst can be characterized using several analytical techniques for both the fresh and recycled ones, demonstrating that there is no activity or stability loss during four reaction cycles. [Display omitted]