A sulfone-based fluorogenic probe for cascade detection of Zn2+ and PO43− ions

• Published in: Journal of molecular structure 2024-05, Vol.1304, p.137736, Article 137736
• Main Authors: Chourasia, Jyoti, Tohora, Najmin, Mahato, Manas, Sultana, Tuhina, Ahamed, Sabbir, Maiti, Arpita, Ghanta, Susanta, Das, Sudhir Kumar
• Format: Article
• Language: English
• Subjects: CHEF; Fluorogenic; ICT; Paper strip; Turn on
• ISSN: 0022-2860
• DOI: 10.1016/j.molstruc.2024.137736

•A Sulfone-based fluorogenic probe, ASSA, has been introduced for cascade detection of Zn2+ and PO43− ions.•An instant green fluorescence is observed due to the chelation of Zn2+ ions with ASSA.•The chelation of Zn2+ ions with ASSA is in a 1:1 stoichiometric ratio with a binding constant of 2.6 × 105 M−1.•The detection limit of Zn2+and PO43− ions is 16.65 nM and 0.134 μM, respectively.•A handy paper strips-based has been fabricated to recognize Zn2+ ions. Detection of trace amounts of metal and non-metal ions is environmentally and biologically significant. In the present contribution, we have introduced a fluorogenic 4,4-diaminodiphenylsulphone-based probe, ASSA, which instantly detects Zn2+ions in its solid and liquid medium. With the implementation of Zn2+ions to the ASSA solution, an instant green fluorescence is observed at 485 nm due to the chelation of Zn2+ ions with ASSA with a stoichiometric ratio of 1:1, evident from the Job's plot and revealed binding constant as 2.6 × 105 M−1. This green fluorescence is reversed in the presence of PO43− ions, proving that our modeled fluorosensor could be a reliable candidate for the cascade detection of Zn2+ and PO43− ions. Along with our modeled fluorosensor, ASSA bears an outstanding selectivity and targeted sensitivity with a detection limit of Zn2+and PO43− ions as 16.65 nM and 0.134 μM, respectively, in a 10 % H2O-DMSO medium. A super handy paper-cuts-based experiment has been performed to recognize and quantify Zn2+ ions in the Cd2+, Hg2+, and other metals crowding situation. Also, we have constructed an INHIBIT logic gate based on the "on-off" fluorescence behavior of ASSA towards Zn2+ ions. A Sulfone-based fluorogenic probe, ASSA, has been introduced for cascade detection of Zn2+ and PO43− ions displaying off-on-off green fluorescence with the detection limit of 16.65 nM and 0.134 μM, respectively. [Display omitted]