Investigation on the pharmacological profile for new synthesized bis heterocyclic analogs containing nitrogen atom as anti-cancer therapy target

• Published in: Journal of molecular structure 2024-09, Vol.1312, p.138450, Article 138450
• Main Authors: Kassem, Asmaa F., Moustafa, Gaber O., Omran, Mervat M., El-Sofany, Walaa I.
• Format: Article
• Language: English
• Subjects: Anticancer activity; FaDu; H460; Huh7; Pyrazole; Pyridine
• ISSN: 0022-2860
• DOI: 10.1016/j.molstruc.2024.138450

•New heteocyclic derivatives containing pyridine and pyrazole have been synthesized successfuly.•All newly produced compounds were characterized using mass, NMR, and IR spectra.•The new compounds were tested for anticancer effects on human cell lines (H460), (FaDu), and (Huh7).•Compounds 3, 8, 11 and 16 are secure and specific because their IC50 values on normal cell line are higher than their IC50 values on tested cancer cell lines. Cancer is a common public health disease causing mortality worldwide. Thus, providing novel chemotherapies that tackle breast cancer is of great interest. In this investigation, novel heterocyclic compounds with pyridine, pyrimidine, and pyrazole rings 2–16 were synthesized and characterized using a variety of spectrum analyses. All synthesized compounds were evaluated for their anticancer effects on human lung carcinoma cell line (H460), human pharynx squamous cell carcinoma cell line (FaDu), and common human hepatocellular carcinoma cell line (Huh7), compounds 3 (6-ethoxy-pyridine), 8 (pyridinyl-pyrazol), 9 (pyridinyl-N, N-diacetylpyrazol), 11 (pyridinyl-N-(2,4-dinitrophenyl)pyrazole), 13 (pyridinyl-isoxazole) and 16 (pyridinyl-benzo[b][1,4]thiazepine) had the maximum anticancer activity against all examined cell lines. Based on these resultss, we are able to conclude that analoges 6-Ethoxy-pyridine 3, Pyridinyl-pyrazol 8, Pyridinyl-N-(2,4-dinitrophenyl)pyrazole 11 and Pyridinyl-benzo[b][1,4]thiazepine 16 are found to be secure and specific because their IC50 values on normal cell line are higher than their IC50 values on tested cancer cell lines. [Display omitted]