Copper and silver nano-schiff base complexes: Efficient catalysts for triazole synthesis and antimicrobial assessment

• Published in: Journal of molecular structure 2024-11, Vol.1316, p.138910, Article 138910
• Main Authors: saleh, Dalia I, Alhashmialameer, Dalal, Mahmoud, Samy F., Etaiw, Safaa Eldin H.
• Format: Article
• Language: English
• Subjects: 1,2,3-triazoles; Antimicrobial activity; Catalysis; Copper and silver-complexes; One pot reaction; Schiff base
• ISSN: 0022-2860
• DOI: 10.1016/j.molstruc.2024.138910

•Two nano-Schiff base complexes [CuSB1] and [AgHSB2] were investigated by physical and spectroscopic measurements.•The optimized geometrical structures of H2SB, 1, 2 and HOMO–LUMO representations were performed by Cluster calculations.•Cu and Ag atoms form square planar and tetrahedral geometries, respectively.•1 and 2 exhibit efficient catalytic activity to prepare different triazoles (3–8). using single pot selective cycloaddition reaction.•The activity of compounds 1–4 against the antimicrobial and fungi had been tested by disc diffusion method. 1,2,3-Triazoles are one of the most important nitrogen-containing five-membered heterocycles and have a wide range of applications in pharmaceuticals, chemical biology, and industry. Therefore, the development of facile and straightforward methodology for the synthesis of 1,2,3-triazoles is of noteworthy interest. Click chemistry represents the most facile, easy and one pot reaction method to synthesize catalyzed azide–alkyne cycloaddition reaction. Nano-scaled bis(2‑hydroxy-1-naphthylmethylidene) ethane-1,2-diamine copperII [CuSB1] and nano-silver ethane-1,2-diamine bis(2-hydroxy-1-naphthylmethylidene) [AgHSB2] complexes where H2SB= 1,2-diamino ethane-N,N’-bis(2-hydroxy-1-naphthylmethylidene), were synthesized utilizing ultrasonic green method. The catalysts were examined by elemental analyses, molar conductance, and spectrophotometric tests. The optimized geometrical structures of H2SB, [CuSB1], [AgHSB2], and HOMO–LUMO representations were performed by Cluster calculations using DMOL3 program. TEM images showed narrower morphology and regular nanostructures of the catalysts. CuSB1] and [AgHSB2] exhibit efficient catalytic activity to prepare different triazoles (3–8). using single-pot selective cycloaddition reaction within very short time and excellent yield without presence of biproducts. The complexes [CuSB1], [AgHSB2] and the triazoles 3, 4, as representative examples, have efficient antimicrobial activity making them promising drugs for treating the bacterial and fungal infections. [Display omitted]