1,4-Bis(pyridin-1-ium)benzene trifluoroacetate coordinated to chloropropyl functionalized SiO2-nano-NiFe2O4 (BPBTCSF): As a novel and effectual mesoporous bi-functional magnetic catalyst for the synthesis pyrido[2,3-d:6,5-d']dipyrimidines

• Published in: Journal of molecular structure 2025-02, Vol.1323, p.140671, Article 140671
• Main Authors: Hsu, Chou-Yi, Alshahrani, Mohammad Y, Jadeja, Yashwantsinh, Oghenemaro, Enwa Felix, Nathiya, Deepak, Kaur, Parjinder, Aulakh, Damanjeet, Rao, Devendra Pratap, Wais, Alaa Mohammed Hussein, alzahra, Farah abd
• Format: Article
• Language: English
• Subjects: Bi-functional catalyst; BPBTCSF; Mesoporous nanomagnetic catalyst; Multi-component reactions. Pyrido-dipyrimidines; SiO2-nano-NiFe2O4
• ISSN: 0022-2860
• DOI: 10.1016/j.molstruc.2024.140671

•Bi-functional magnetic catalyst with SiO2@NiFe2O4 core.•Heterogeneous catalyst system with acidic and basic sites.•Rapid synthesis of pyrido[2,3-d:6,5-d']dipyrimidines.•Multicomponent reaction in water-green solvent at 25 °C.•Represents advantages: appropriate reproducibility of the catalyst (6 runs), high TOF and TON numbers, easy separation by filtration in the presence of an external magnet, high efficiency (90 % to 98 %), and compliance with the principles of green chemistry. Here in, we report the synthesis of 1,4-Bis(pyridin-1-ium)benzene trifluoroacetate coordinated to chloropropyl functionalized SiO2-nano-NiFe2O4 (BPBTCSF). Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), elemental mapping analysis, Brunauer-Emmett-Teller (BET), thermal gravimetric analysis (TGA), vibrating-sample magnetometry (VSM) and X-ray diffraction (XRD) techniques characterized the framework of this catalyst. The catalytic activity of this nano-composite was then examined in the one-pot four-component reaction of 2-thiobarbituric acid, NH4OAc, and aldehyde for synthesis of pyrido[2,3-d:6,5-d']dipyrimidines under optimal conditions (5 mg of BPBTCSF, H2O, 25 °C). BPBTCSF exhibits benefits as a heterogeneous catalyst, such as exciting performance in the production of derivatives (2 to 5 min, 90 % to 98 %), six times reproducibility with a slight decrease in catalytic activity, the simultaneous presence of acidic and basic sites (Hydrogen attached to the electronegative nitrogen atom and CF3COOˉ, respectively), convenient purification and separation from the reaction mixture. [Display omitted]