Omics and anaesthesia: pharmacogenomics, proteomics and metabolomics

The inter-individual response to medications and the presence of genetic polymorphisms which impact the safe conduct of anaesthesia and analgesia are of paramount importance to the anaesthetist, intensivist and pain physician. The frequency of these phenomena is not reflected in the attention afford...

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Bibliographic Details
Published in:Anaesthesia and intensive care medicine 2019-04, Vol.20 (4), p.248-253
Main Authors: Walton, Thomas E.F., Rajan, Jonathan N.
Format: Article
Language:English
Subjects:
Cytochrome
metabolomics
neurotransmitter
Omics
pharmacogenetics
pharmacogenomics
proteomics
receptor
single nucleotide polymorphism
transporter
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Summary:The inter-individual response to medications and the presence of genetic polymorphisms which impact the safe conduct of anaesthesia and analgesia are of paramount importance to the anaesthetist, intensivist and pain physician. The frequency of these phenomena is not reflected in the attention afforded them in undergraduate or postgraduate curricula. In order to appreciate how these issues may affect our clinical practice, it is crucial to have a working understanding of the concepts that underpin the relevant fields within the collection of disciplines we term the ‘omics’.
ISSN:1472-0299
1878-7584
DOI:10.1016/j.mpaic.2019.01.019