Peripheral nerve sheath tumors: an update and review of diagnostic challenges

Abstract Peripheral nerve sheath tumors (PNSTs) are one of the more common soft tissue neoplasms encountered in the daily surgical pathology practice, most of which have classic histologic features. There are, however, some common diagnostic challenges encountered by surgical pathologists and neurop...

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Bibliographic Details
Published in:Diagnostic histopathology (Oxford, England : 2008) England : 2008), 2016-11, Vol.22 (11), p.447-457
Main Authors: De Luca-Johnson, Javier, Kalof, Alexandra N
Format: Article
Language:English
Subjects:
hybrid nerve sheath tumors
malignant peripheral nerve sheath tumor
neurofibroma
Pathology
perineurioma
peripheral nerve
schwannoma
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Summary:Abstract Peripheral nerve sheath tumors (PNSTs) are one of the more common soft tissue neoplasms encountered in the daily surgical pathology practice, most of which have classic histologic features. There are, however, some common diagnostic challenges encountered by surgical pathologists and neuropathologists, as well as controversies regarding classification and grading of PNSTs. As molecular studies advance and novel targeted therapies are developed, it has become imperative that we become familiar with the diagnostic criteria for these common neoplasms and their potential mimics.
ISSN:1756-2317
1876-7621
DOI:10.1016/j.mpdhp.2016.10.008