Minimal change disease complicated by contrast-induced nephropathy

We present a clinical case with histopathological findings of an adult presentation of nephrotic syndrome complicated by acute kidney injury (AKI) following a CT contrast study. A 45-year old female with no significant past medical history was admitted following a 1 week history of peripheral oedema...

Full description

Saved in:
Bibliographic Details
Published in:Diagnostic histopathology (Oxford, England : 2008) England : 2008), 2021-04, Vol.27 (4), p.167-169
Main Authors: Shotton, Kieran P., Wagner, Bart E., Chinnappa, Shanmugakumar, Al-Omari, Ali
Format: Article
Language:English
Subjects:
acute kidney injury
acute tubular injury
electron microscopy images
histopathology
nephrotic syndrome
renal biopsy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We present a clinical case with histopathological findings of an adult presentation of nephrotic syndrome complicated by acute kidney injury (AKI) following a CT contrast study. A 45-year old female with no significant past medical history was admitted following a 1 week history of peripheral oedema. She developed AKI following CT abdomen and pelvis with contrast, before being transferred to the renal team and being diagnosed with nephrotic syndrome. Histopathological assessment of a renal biopsy displayed evidence of both acute tubular injury and minimal change disease (MCD). To the author's knowledge, this is the first documented case of MCD complicated by contrast-induced nephropathy, with evidence of both pathologies on electron microscopy. Clinically, such cases emphasise the need for awareness of susceptibility to AKI in patients with MCD.
ISSN:1756-2317
1876-7621
DOI:10.1016/j.mpdhp.2021.01.005