Radiological studies of fetal alcohol spectrum disorders in humans and animal models: An updated comprehensive review

Abstract Fetal Alcohol Spectrum Disorders encompass a wide range of birth defects in children born to mothers who consumed alcohol during pregnancy. Typical mental impairments in FASD include difficulties in life adaptation and learning and memory, deficits in attention, visuospatial skills, languag...

Full description

Saved in:
Bibliographic Details
Published in:Magnetic resonance imaging 2017-11, Vol.43, p.10-26
Main Authors: Nguyen, Van T, Chong, Suyinn, Tieng, Quang M, Mardon, Karine, Galloway, Graham J, Kurniawan, Nyoman D
Format: Article
Language:English
Subjects:
Animals
Attention
Brain - diagnostic imaging
Brain - metabolism
Brain Mapping
Child
Ethanol
FASD
Female
Fetal Alcohol Spectrum Disorders - diagnostic imaging
Gray Matter - diagnostic imaging
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Memory, Short-Term
Mental Disorders - diagnostic imaging
Mice
Mice, Inbred C57BL
Models, Animal
Phenotype
Positron-Emission Tomography
Pregnancy
Prenatal alcohol exposure
Prenatal Exposure Delayed Effects - diagnostic imaging
Radiology
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed
Translational Medical Research
White Matter - diagnostic imaging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Fetal Alcohol Spectrum Disorders encompass a wide range of birth defects in children born to mothers who consumed alcohol during pregnancy. Typical mental impairments in FASD include difficulties in life adaptation and learning and memory, deficits in attention, visuospatial skills, language and speech disabilities, mood disorders and motor disabilities. Multimodal imaging methods have enabled in vivo studies of the teratogenic effects of alcohol on the central nervous system, giving more insight into the FASD phenotype. This paper offers an up-to-date comprehensive review of radiological findings in the central nervous system in studies of prenatal alcohol exposure in both humans and translational animal models, including Magnetic Resonance Imaging, Computed Tomography, Positron Emission Tomography, Single Photon Emission Tomography and Ultrasonography.
ISSN:0730-725X
1873-5894
DOI:10.1016/j.mri.2017.06.012