DNA and chromosome damage induced by bleomycin in mammalian cells: An update

Bleomycin (BLM) is an antibiotic isolated from Streptomyces verticillus. It has radiomimetic actions on DNA thus it has been widely used in clinical chemotherapy for the treatment of different types of cancer, including head and neck tumors, lymphomas, squamous-cell carcinomas and germ-cell tumors....

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Bibliographic Details
Published in:Mutation research. Reviews in mutation research 2018-01, Vol.775, p.51-62
Main Authors: Bolzán, Alejandro D., Bianchi, Martha S.
Format: Article
Language:English
Subjects:
Bleomycin
Chromosomal aberrations
DNA damage
Genotoxicity
Telomere
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Summary:Bleomycin (BLM) is an antibiotic isolated from Streptomyces verticillus. It has radiomimetic actions on DNA thus it has been widely used in clinical chemotherapy for the treatment of different types of cancer, including head and neck tumors, lymphomas, squamous-cell carcinomas and germ-cell tumors. Because of this, the study of BLM genotoxicity is of practical interest. This antibiotic is an S-independent clastogen and an agent that generates free radicals and induces single- and double-strand breaks in DNA. In the present review, we will summarize our current knowledge concerning the DNA and chromosome damage induced by BLM in mammalian cells, with emphasis on new developments published since 1991.
ISSN:1383-5742
1388-2139
DOI:10.1016/j.mrrev.2018.02.003