Biocomposites composed of natural rubber latex and cartilage tissue derived from human mesenchymal stem cells

Natural rubber latex (NRL) is mainly used for traditional industrial products, but currently, its target application is continuously expanding into tissue engineering. Here, we have presented the chondrogenesis ability of NRL nanoparticles against human mesenchymal stem cells (hMSCs). The effective...

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Bibliographic Details
Published in:Materials today chemistry 2019-06, Vol.12, p.315-323
Main Authors: Kinoshita, M., Okamoto, Y., Furuya, M., Okamoto, M.
Format: Article
Language:English
Subjects:
Cell cycle distribution
Chondrogenesis
Cytotoxicity
hMSC spheroid
Mechanical properties
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Summary:Natural rubber latex (NRL) is mainly used for traditional industrial products, but currently, its target application is continuously expanding into tissue engineering. Here, we have presented the chondrogenesis ability of NRL nanoparticles against human mesenchymal stem cells (hMSCs). The effective gene expression of in vitro chondrogenesis of hMSCs with administration of NRL was confirmed as revealed by the chondrogenic gene expression analysis. We have successfully for the first time fabricated the cartilage/NRL biocomposites via hMSC spheroid formation, where the administration of NRL nanoparticles exhibited the mechanically stable structure with hard surface structure in the spheroid. [Display omitted] •Cartilage/natural rubber latex (NRL) biocomposite with stiff surface via human mesenchymal stem cell (hMSC) spheroid formation.•Gene expression of SOX9, aggrecan, and collagen type-II and proteoglycan formation were high.•Effective gene expression of chondrogenesis of hMSCs with administration of NRL.
ISSN:2468-5194
2468-5194
DOI:10.1016/j.mtchem.2019.03.002